中文名 | 丹酚酸 A |
英文名 | Salvianolic acid A |
别名 | 丹酚酸A 丹酚酸 A 丹参酚酸A 丹酚酸A对照品, 丹酚酸A(标准品) 丹酚酸A(丹参酚酸A) 丹参酚酸A, 来源于丹参根茎 SALVIANOLIC ACID A 丹酚酸A (2R)-3-(3,4-二羟基苯基)-2-[(E)-3-[2-[(E)-2-(3,4-二羟基苯基)乙烯基]-3,4-二羟基苯基]丙-2-烯酰]氧丙酸 |
英文别名 | Salvianolic acid Danphenolic acid A Salvianolic acid A Dan phenolic acid A hydrate Salvianolic acid A, froM Salvia Miltiorrhiza (R)-3-(3,4-Dihydroxyphenyl)-2-(((E)-3-(2-((E)-3,4-dihydroxystyryl)-3,4-dihydroxyphenyl)acryloyl)o (R)-3-(3,4-Dihydroxyphenyl)-2-(((E)-3-(2-((E)-3,4-dihydroxystyryl)-3,4-dihydroxyphenyl)acryloyl)oxy)propanoic acid 3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-{2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl}prop-2-enoyl]oxy}propanoic acid (2R)-3-(3,4-Dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]prop-2-enoyl]oxypropanoic acid (2R)-3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-{2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl}prop-2-enoyl]oxy}propanoic acid (αR)-α-[[(2E)-3-[2-[(1E)-2-(3,4-Dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxybenzenepropanoic acid |
CAS | 96574-01-5 |
化学式 | C26H22O10 |
分子量 | 494.45 |
InChI | InChI=1/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+ |
InChIKey | YMGFTDKNIWPMGF-UCPJVGPRSA-N |
密度 | 1.580±0.06 g/cm3(Predicted) |
熔点 | 164-167°C |
沸点 | 858.7±65.0 °C(Predicted) |
比旋光度 | +41°(c=0.099,Ethanol) |
闪点 | 292.9°C |
蒸汽压 | 2.04E-31mmHg at 25°C |
溶解度 | H2O: ≥ 19 mg/mL |
折射率 | 1.789 |
酸度系数 | 2.78±0.10(Predicted) |
存储条件 | 2-8°C |
敏感性 | Easily absorbing moisture |
外观 | 粉末 |
颜色 | yellow |
BRN | 2660108 |
物化性质 | 黄色针状结晶,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于丹参根茎。 |
MDL号 | MFCD20527310 |
体内研究 | A significant beneficial effect of Salvianolic acid A (SAA) is observed in the Salvianolic acid A treatment groups. Salvianolic acid A (20 mg/kg) could significantly prolonged the retention time of rats on the plate. While compared with sham operation group, the brain water content in model group significantly increases, which is attenuated significantly by Salvianolic acid A (10 and 20 mg/kg). Compared with the model group, Salvianolic acid A (5, 10, and 20 mg/kg) could maintain the normal structures of neurons and increase neurons number. It is also found that Salvianolic acid A (20 mg/kg) could significantly reduce I/R induced MMP-9 upregulation. While the MMP-2 expression is not significantly affected by Salvianolic acid A. Tissue inhibitors of metalloproteinases (TIMPs) could inhibit the activity of MMPs through high affinity binding to MMPs catalytic domain. |
安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
WGK Germany | 3 |
海关编号 | 29189900 |
参考资料 展开查看 | 1. 张素清 虞立 范红晶 等. 丹参中丹酚酸A在高温高压条件下的转化提取工艺研究[J]. 中华中医药学刊 2017 035(012):3084-3087. 2. 姜峰 李飏 张敏 等. 丹参中丹酚酸A转化方法[J]. 中成药 2018 40(009):2091-2096. 3. 彭九嫚, 柴尧, 潘旻,等. 丹参中酚酸类成分在不同工艺条件下转化关系[J]. 中国实验方剂学杂志, 2016, 022(005):67-70. 4. 黄莎莎 赵文静 张悦 等. 中药酚酸类成分在PES膜分离过程中的透过机制研究[J]. 中国中药杂志 2020 v.45(01):114-120. 5. 邢志华, 包然, 姜婧雯,等. 芹菜素-钐配合物的合成及其抗小鼠高尿酸血症研究. 天然产物研究与开发. 6. 冯思念 王瑞 顾雯 等. 不同强度的红蓝光质对丹参根系形态和有效成分积累的影响[J]. 中草药 2019(21). 7. 马东来 刘爱朋 林悦 谢赟 刘涛 朱峰莉 楚立.丹参有效成分与铁离子的相互作用[J].广州化工 2017 45(14):117-118+144. 8. 李正, 潘万芳, 朱立明,等. 基于物质流分析的丹红注射液制药过程质量控制研究[J]. 天津中医药大学学报, 2015, 34(06):349-352. 9. 赵志国, 段文娟, 张晓梦,等. HPLC-DAD-ESI-TOF/MS鉴别和测定前列欣胶囊中多种成分及其多指标定量指纹图谱研究[J]. 药物分析杂志, 2017, 037(010):1810-1816. 10. 王芸, 陈军峰, 张磊,等. 基于"有效成分-性状"的关联分析评价丹参品质的研究[J]. 世界科学技术:中医药现代化, 2019(5):835-843. 11. 黑小斌,李欢,李慧,梁小燕,高静,彭亮,李依民,张岗.丹参无菌培养体系构建及有效成分含量的HPLC分析[J].中草药,2020,51(22):5833-5838. 12. 乐世俊,王文晓,高欢,任继国,付瑞嘉,李佳佳,陈艳琰,唐于平.HPLC同时测定不同厂家丹七片中多个有效成分的含量[J].药物分析杂志,2020,40(12):2236-2243. 13. Wang, Jixia, et al. "Discovery of new targets of phenolic acids in danshen using a label-free cell phenotypic assay." RSC Advances 5.33 (2015): 25768-25776.https://doi.org/10.1039/C4RA16102E 14. Zhou, Jing, et al. "A strategy for rapid discovery of traceable chemical markers in herbal products using MZmine 2 data processing toolbox: A case of Jing Liqueur." Chinese Herbal Medicines (2021). 15. [IF=4.759] Yanmei Zhang et al."Screening of mammalian target of rapamycin inhibitors in natural product extracts by capillary electrophoresis in combination with high performance liquid chromatography–tandem mass spectrometry."J Chromatogr A. 2015 Apr;1388:267 16. [IF=3.049] Jixia Wang et al."Discovery of new targets of phenolic acids in danshen using a label-free cell phenotypic assay."Rsc Adv. 2015 Mar;5(33):25768-25776 17. [IF=2.943] Zheng Chunli et al."System-level multi-target drug discovery from natural products with applications to cardiovascular diseases."Mol Divers. 2014 Aug;18(3):621-635 18. [IF=3.216] Shuang Feng et al."Salvianolic Acid A Exhibits Anti-Inflammatory and Antiarthritic Effects via Inhibiting NF-κB and p38/MAPK Pathways."Drug Des Dev Ther. 2020; 14: 1771–1778 19. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 20. [IF=9.078] Jun Qian et al."A strategy for effective recovery of salvianolic acid a from Salvia miltiorrhiza (Danshen) through multiple interactions."Compos Part B-Eng. 2022 Feb;231:109563 21. [IF=3.935] Yaqing Guo et al."An integrated strategy for the systematic chemical characterization of Salvianolate lyophilized injection using four scan modes based on the ultra-high performance liquid chromatography-triple quadrupole-linear ion trap mass spectrometry. |
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